Everyday living-Threatening Respiratory Depression Tell clients of the potential risk of life-threatening respiratory melancholy, including details that the danger is finest when starting promethazine HCl and codeine phosphate oral Answer and that it may arise even at proposed dosages [see Warnings and Safety measures (five.
g., amiodarone, quinidine) may well end in an increase in codeine plasma concentrations in addition to a minimize in Energetic metabolite morphine plasma focus which could bring about an analgesic efficacy reduction or symptoms of opioid withdrawal.
Breathing issues (respiratory melancholy) that can result in Loss of life and opioid withdrawal can materialize if You begin getting or end taking other medicines when having Promethazine Hydrochloride and Codeine Phosphate Oral Solution, together with:
“For other generic producers, it depends upon what their manufacturing is and the amount extra skill they may have inside their production plants to select up and make added goods,” Kann explained.
are breastfeeding or want to breastfeed. Codeine passes into your breast milk and could potentially cause significant side effects in the newborn like greater sleepiness, respiration issues (respiratory melancholy), and Demise. It's not necessarily acknowledged if promethazine can go into your breast milk.
Because these reactions could be documented voluntarily from the inhabitants of unsure size, It is far from usually achievable to reliably estimate their frequency or create a causal connection to drug exposure.
In a few kids and Grownups this here comes about very quickly, and may cause you to stop breathing and bring about Demise due to an overdose.
One example is, quite a few noted circumstances of Dying happened within the article-operative period adhering to tonsillectomy and/or adenoidectomy, and several of the youngsters had evidence of getting ultra-quick metabolizers of codeine. Also, children with obstructive rest apnea who will be treated with codeine for post-tonsillectomy and/or adenoidectomy discomfort could possibly be especially sensitive to its respiratory depressant impact. Because of the risk of lifestyle-threatening respiratory depression and Demise:
Store items from compact business manufacturers offered in Amazon’s keep. Uncover more details on the modest enterprises partnering with Amazon and Amazon’s dedication to empowering them. Find out more
The following serious adverse reactions are described, or explained in higher depth, in other sections:
Even with this, Kann observed that the loss of Akorn Prescription drugs may lead to drug shortages if other generic makers are unable to satisfy the requirements of the individuals who ended up Formerly dealt with with prescription drugs well prepared by Akorn.
There aren't any accessible info with promethazine HCl and codeine phosphate oral Resolution use in Expecting Gals to tell a drug-connected hazard for adverse developmental outcomes.
Shop products from little small business models marketed in Amazon’s shop. Find more details on the modest firms partnering with Amazon and Amazon’s commitment to empowering them. Learn more
These remedies may be used to treat and end ulcers inside the belly, assist with bowel syndrome, soften the stool, alleviate constipation, or help with high blood pressure.